Angiotensin-converting enzyme 2 (ACE2)
Links to databases
ACE2 is a carboxypeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin 1-9, or the conversion of angiotensin II to the vasodilator peptide angiotensin 1-7. It is expressed in a wide range of cell types, but notably in vascular endothelial cells of the heart and the kidneys. ACE2 is an important regulator of heart function and also serves as functional receptor for the spike glycoprotein of some coronaviruses, including SARS.
Sample type
Analytical Measuring Range
Please note: the technical data reported below refers to the measured value in the in vitro validation assays. The calibrator curve below shows the performance of the assay with the estimated sensitivity and dynamic range parameters indicated. These curves are generated during the assay validation process using recombinant antigens. Please note that when analyzing biological samples the data generated will be given in the form of relative quantification (NPX values) and cannot be converted to absolute protein concentrations. For more info about NPX measurements, please visit our FAQ page (https://www.olink.com/question/what-is-npx).
- LOD (pg/mL)
- 15.26
- LLOQ (pg/mL)
- 15.26
- ULOQ (pg/mL)
- 62500
- Hook (pg/mL)
- 1000000
- Range (logs)
- 3.6
Calibrator curve for validation data (generated in multiplex)
Precision
- Within run precision Coefficient of Variation (CV)
- 8%
- Between run precision Coefficient of Variation (CV)
- 11%
Precision (repeatability) is calculated from linearized NPX values over LOD.
Biomarker Validation Data
Additional validation data, as well as a more detailed description of how the Olink panels are quality controlled can be found in our Data Validation documents. To download or to learn more go to the Data Validation page.
